Stereochemistry of the C and D rings of C-nor-D-homosteroid. IV. The relative stabilities and NMR spectra of 17-substituted C/D trans- and cis-fused etiojervanes.
スポンサーリンク
概要
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(1) The relative stabilities between 17-substituted C/D <I>trans</I>- and <I>cis</I>-fused 11-oxoetiojervanes were investigated by treatment of both or either one of these 12-epimeric compounds under equilibrating conditions. The equilibrium ratios thus obtained were estimated qualitatively in terms of the configuration and bulkiness of substituent(s) at C<SUB>17</SUB>. (2) The chemical shifts of 19- and 18-methyl protons in a number of etiojervanes were examined collectively. The "principle of additivity" holds satisfactorily for the 19-methyl protons of all etiojervanes, with two exceptional cases, irrespective of the configuration at C<SUB>12</SUB> and also for the 18-methyl protons of 12β-etiojervanes. However, the principle is not applicable for the latter protons of 12α-etiojervanes, suggesting that the D ring would take different conformations depending on the 17-substituents.
- 公益社団法人 日本化学会の論文
著者
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Murai Akio
Department Of Chemistry Faculty Of Science Hokkaido University
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Numata Satoshi
Department Of Environmental Biology And Chemistry Faculty Of Science University Of Toyama
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Masamune Tadashi
Department Of Chemistry Faculty Of Science Hokkaido University
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Sasamori Hiroshi
Department of Chemistry, Faculty of Science, Hokkaido University
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Nishizakura Kouichi
Department of Chemistry, Faculty of Science, Hokkaido University
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Orito Takako
Department of Chemistry, Faculty of Science, Hokkaido University
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Numata Satoshi
Department of Chemistry, Faculty of Science, Hokkaido University
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