Studies on biologically active pteridines. IV. Synthesis of several biopterin derivatives as an antigen in radioimmunoassay for biopterin.
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概要
- 論文の詳細を見る
The synthesis of biopterin, D(and L)-<I>erythro</I>-neopterins, and their derivatives having a substituent at the 2-amino group <I>via</I> the 2-methylthio analogues is described. The 2-(methylthio)pteridines were synthesized by condensation of 4,5-diamino-6-hydroxy-2-(methylthio)pyrimidine with 5-deoxy-L-arabinose and D(and L)-arabinose phenylhydrazones, followed by oxidation with K<SUB>3</SUB>[Fe(CN)<SUB>6</SUB>] and O<SUB>2</SUB> in the presence of KI in an acidic solution, respectively. Aminolysis of these thioethers with ammonia and other amines in the presence of acetic acid gave the title compounds.
- 公益社団法人 日本化学会の論文
著者
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Nagatsu Toshiharu
Laboratory Of Cell Physiology Department Of Life Chemistry Graduate School At Nagatsuta
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Matsuura Sadao
Department Of Chemistry College Of General Education Nagoya University
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Sugimoto Takashi
Department Of Chemical Engineering And Materials Science Faculty Of Engineering Doshisha University
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