Imidazopteridines. II. Synthesis of imidazo[1,2-c]pteridines with a functional group at the 6-position.
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概要
- 論文の詳細を見る
Several imidazo[1,2-<I>c</I>]pteridines with a functional group such as amino, alkylamino, alkoxyl, or hydroxyl group at the 6-position were synthesized by a nucleophilic replacement of 6-methylthioimidazo[1,2-<I>c</I>]pteridine with an appropriate nucleophile. The key intermediate methylthio compound was synthesized by condensation of 4-amino-2-methylthiopteridine with chloroacetaldehyde. Similarly, 4-amino-6,7-dimethyl-2-methylthiopteridine and chloroacetaldehyde gave 2,3-dimethyl-6-methylthioimidazo[1,2-<I>c</I>]pteridine, which was also used as a precursor to synthesize several imidazopteridines analogous to above.
- 公益社団法人 日本化学会の論文
著者
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Matsuura Sadao
Department Of Chemistry College Of General Education Nagoya University
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Sugimoto Takashi
Department Of Chemical Engineering And Materials Science Faculty Of Engineering Doshisha University
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Shibata Keiko
Department of Chemistry, College of General Education, Nagoya University
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