Studies on biologically active pteridines. II. Synthesis of some 2-pyrimidinyl- and 2-pteridinyl-amino acids.
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概要
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Synthesis of some pyrimidines and pteridines with an amino acid residue at the 2-position was investigated. 4-Ammo-6-hydroxy-2-methylthio-5-nitrosopyrimidine, on heating with amino acids in water, underwent aminolysis at the 2-position to give the corresponding <I>N</I>-(4-amino-6-hydroxy-5-nitroso-2-pyrimidinyl) amino acids. These (5-nitroso-2-pyrimidinyl)amino acids, after reduction of the nitroso group to an amino group, condensed with biacetyl or a pentose phenylhydrazone to give <I>N</I>-(4-hydroxy-6,7-dimethyl-2-pteridinyl) amino acids and <I>N</I>-(4-hydroxy-6-polyhydroxypropyl-2-pteridinyl) amino acids, respectively.
- 公益社団法人 日本化学会の論文
著者
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Nagatsu Toshiharu
Laboratory Of Cell Physiology Department Of Life Chemistry Graduate School At Nagatsuta
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Matsuura Sadao
Department Of Chemistry College Of General Education Nagoya University
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Sugimoto Takashi
Department Of Chemical Engineering And Materials Science Faculty Of Engineering Doshisha University
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Shibata Keiko
Department of Chemistry, College of General Education, Nagoya University
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