Oxidative cleavage reaction of 3-substituted indoles catalyzed by CuCl-pyridine complex under oxygen.
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概要
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Oxidative cleavage of 3-methylindole using a catalytic amount of copper(II) salts with added pyridine under an oxygen atmosphere was studied. Smooth cleavage of 3-methylindole took place to give 2-formamidoacetophenone in 73–80% yield, whereas exclusive formation of a hydrate compound derived from 3,3′-dimethyl-3,3′-bi-3<I>H</I>-indole resulted under anaerobic conditions. Clean oxidative cleavage of <I>N</I>-acetyltryptamine, methyl 3-indolylacetate, and methyl 2-acetamido-3-(3-indolyl)propionate was also achieved, constituting a mimic of tryptophan-2,3-dioxygenase.
- 公益社団法人 日本化学会の論文
著者
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TSUJI Jiro
Department of Chemical Technology, Kurashiki University of Science and the Arts
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Yamamoto Keiji
Department Of Applied Physics Faculty Of Engineering Tokyo University
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Takayanagi Hiroshi
Department Of Cell Signaling Graduate School Of Medical And Dental Sciences Tokyo Medical And Dental
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Kezuka Hiroaki
Department of Anatomy, St. Marianna University School of Medicine
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Kezuka Hiroaki
Department of Chemical Engineering, Tokyo Institute of Technology
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