Highly selective carbon-carbon bond forming reactions mediated by chromium(II) reagents.
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概要
- 論文の詳細を見る
A low valent chromium reagent is generated from chromium(III) chloride and a half mol of lithium aluminum hydride in tetrahydrofuran. The reagent behaves similarly to anhydrous chromium(II) chloride, which is commercially available, and reduces allylic halides to produce unisolable allylchromium species which add efficiently to aldehydes or ketones with high degree of stereo- and chemoselectivity. Particularly, high <I>threo</I> selectivity is observed in the reaction of aldehydes and 1-bromo-2-butene and is ascribed to a chair-like six-membered transition state. Simple reduction of allylic and benzylic halides produces biallyls and bibenzyls, while <I>gem</I>-dibromocyclopropanes afford the corresponding allenes in excellent yields.
- 公益社団法人 日本化学会の論文
著者
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Kimura Keizo
Department Of Cardiovascular Medicine Wakayama Medical University
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Hiyama Tamejiro
Department Of Marerial Chemistry Graduate School Of Engineering Kyoto University
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Nozaki Hitosi
Department of Industrial Chemistry, Kyoto University
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Kimura Keizo
Department of Industrial Chemistry, Kyoto University
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Okude Yoshitaka
Department of Industrial Chemistry, Kyoto University
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Nozaki Hitosi
Department of Industrial Chemistry, Faculty of Engineering Kyoto University
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Hiyama Tamejiro
Department of Industrial Chemistry, Faculty of Engineering, Kyoto University
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