The preparation of N-protected amino alcohols and N-protected peptide alcohol by reduction of the corresponding esters with sodium borohydride. An improved procedure involving a slow addition of a small amount of methanol.
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概要
- 論文の詳細を見る
Esters of <I>N</I>-protected amino acids and an <I>N</I>-protected peptide were reduced selectively to the corresponding alcohols in high yields using lesser amounts of sodium borohydride than does the conventional method by the slow addition of methanol to the mixture of ester and NaBH<SUB>4</SUB> in <I>t</I>-butyl alcohol or tetrahydrofuran at 50°C.
- 公益社団法人 日本化学会の論文
著者
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Soai Kenso
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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OYAMADA Hidekazu
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo(SUT), and CREST, Ja
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Takase Masako
Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
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