Enantioface-differentiating reactions using (2S,2'S)-2-hydroxymethyl-1-[(1-alkyl-2-pyrrolidinyl)methyl]pyrrolidines as chiral ligands. Addition of lithium derivatives of methyl phenyl sulfide, acetonitrile, N-nitrosodimethylamine, and 2-methylthiothiazoli
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概要
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Optically active oxiranes, β-hydroxy nitrile, β-Hiydroxy <I>N</I>-nitrosoamine, and thiirane were obtained (up to 72% optical purity) by the enantioface-differentiating addition of lithium derivatives of methyl phenyl sulfide, acetonitrile, <I>N</I>-nitrosodimethylamine, and 2-methylthiothiazoline to aldehydes using (2<I>S</I>,2′<I>S</I>)-2-hydroxymethyl-1-[(1-alkyl-2-pyrrolidinyl)methyl]pyrrolidines (<B>1a</B>–<B>f</B>) as chiral ligands. Optical purity of the products depended greatly on the reaction medium (dimethoxymethane or dimethyl ether gave the best results) and the structure of pyrrolidine moieties of <B>1a</B>–<B>f</B>.)
- 公益社団法人 日本化学会の論文
著者
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Mukaiyama Teruaki
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Soai Kenso
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Soai Kenso
Department of Chemistry, Faculty of Science, The University of Tokyo
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