The regioselective side-chain lithiation of 2-methyl-3-thiophenecarboxylic acid.
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概要
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It was found that the dilithium salt (<B>5</B>), which was lithiated at the side-chain of 2-methyl-3-thiophenecarboxylic acid (<B>4</B>), was produced regioselectively by the reaction of <B>4</B> with lithium diisopropylamide (LDA). The reactions of <B>5</B> with alkyl halides resulted in the formation of 2-alkyl-3-thiophenecarboxylic acids (<B>7</B>). Further, δ-lactone derivatives (<B>11</B>) were obtained by the cyclization of the adducts (<B>10</B>) which were produced from <B>5</B> with aldehydes and ketones.
- 公益社団法人 日本化学会の論文
著者
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Kumamoto Takanobu
Department Of Chemistry Faculty Of Science Tokai University
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Shirai Kozo
Department Of Chemistry Faculity Of Science Tokai University
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KUMAMOTO Takanobu
Department of Chemistry, Faculty of Science, Tokai University
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Hui-Wen Su
Department of Chemistry, Faculty of Science, Tokai University
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Hirose Kazuo
Department of Chemistry, Faculty of Science, Tokai University
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