Amidrazones and related compounds. IV. The cyclization of hydrazidines to 2,3,4,5-tetrahydro-1,2,4,5-tetrazine and 4-amino-1,2,4-triazole derivatives.
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概要
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Three methods of cyclization of hydrazidines are described. The reaction of <I>N</I><SUP>4</SUP>-arylhydrazidines (<B>2</B>) with dimethyl acetylenedicarboxylate in refluxing tetrahydrofuran afforded 6-alkyl and aryl-2-aryl-3-methoxycarbonyl-3-methoxycarbonylmethyl-2,3,4,5-tetrahydro-1,2,4,5-tetrazines (<B>3</B>). Oxidation of <I>N</I><SUP>4</SUP>-aryl-<I>N</I><SUP>2</SUP>-arylmethylenehydrazidines (<B>6</B>) with mercuric oxide in refluxing ethanol gave 3-alkyl and aryl-5-aryl-4-arylamino-1,2,4-triazoles (<B>7</B>). 3-Alkyl and aryl-4-arylamino-1,2,4-triazoles (<B>7f</B>, <B>g</B>) were obtained upon the heating of (<B>2a</B>, <B>e</B>) in formic acid.
- 公益社団法人 日本化学会の論文
著者
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Takahashi Masahiko
Department Of Anesthesiology And Emergency Medicine Tohoku University Postgraduate Medical School
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Fukushima Kunio
Department Of Chemistry Faculty Of Science
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Fukushima Kunio
Department of Industrial Chemistry, Faculty of Engineering, Ibaraki University
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Tan Hideya
Department of Industrial Chemistry, Faculty of Engineering, Ibaraki University
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Yamazaki Hiroaki
Department of Industrial Chemistry, Faculty of Engineering, Ibaraki University
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