脾原発悪性リンパ腫の2例

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Two cases of primary splenic malignant lymphoma (PSML) treated with splenectomy followed by chemotherapy are presented. Both patients had splenomegaly but had no superficial lymphnode enlargement were diagnosed or suspected as having primary splenic malignant lymphoma by echography, computed tomography and other examination procedures. One is a 41-year-old male whose spleen obtained by splenectomy was 1800g in weight. Pathological findings of the spleen was non-Hodgkin's diffuse lymphoma, medium size cell type, -B cell lineage according to LSG clasification. After splenectomy hepatic lymphomatous infiltration and abdominal lymphnode involvement were found by echography. Residual lesions were disappeared by following combination chemotherapy. No evidence of reccurent disease has been documented for 2 yeare and 5 months. Another is a 63-year old male whose spleen was 825g in weight. Pathological findings of spleen and splenic hilum lymphnodes was non-Hodgkin's diffuse lymphoma, large cell type, B cell lineage. Abdominal residual lymphnodes and tumor on left diaphragum were enlarged despite chemotherapy-He was died after 9 months.<BR>The ages of PSM L patients usually ranges between 30 and 60 years (average about 50 years), and the male to female ratio is 2: 1. Most patients develop severe splenomegaly averaging 1400g in weight. Pathologically 80% or more of PSML were diffuse lymphoma. Most are of were B cell lineage. PSML involving spleen only or spleen and splenic hilum treatd by splenectomy alone or adjuvant chemotherapy may be potentially curative. PSML with evidence of extrasplenic disease had no favorable prognosis and needs immediate chemotherapy.
Kinki Brain Tumor Pathology Conferenceの論文

脾原発悪性リンパ腫の2例

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