自己末梢血幹細胞移植術を施行した造血器悪性腫瘍3例について- リンパ芽球性リンパ腫症例を中心に-

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The 1st Department of Internal Medicine, Kansai Medical University. The Department of Internal Medicine, Kishiwada City Hospital. The Department of Internal Medicine, Osaka National Hospital Summary High-dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) were performed in two patients with non-Hodgkin's lymphoma (NHL) and a patient with acute lymphoblastic leukemia (ALL). A 13-year-old male with NHL showed lymphoblastic lymphoma histologically, and had mediastinal, pleural and bone marrow involvement. Sufficient peripheral blood stem cells (PBSC) were collected for each patient using CS 3000 cell separator (more than 3×10<SUP>5</SUP> CFU-GM/kg patient weight). In our study all three patients showed recovery of 500/μ1 granulocytes within 8-10 days and 50,000/μ1 platelets within 12-15 days after PBSCT. Both patients with NHL who underwent PBSCT during second remission relapsed within 3 months post-transplant. However, the patient with ALL who received PBSCT during the first remission has continued in remission for 4 months post-transplant.