婦人科悪性腫瘍化学療法時の悪心・嘔吐に対する:Granisetron Hydrochlorideの臨床評価

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we, in the Department of Obstetrics and Gynecology, Kansai Medical College, conducted an evaluation of the usefulness and safety of granisetron hydrochloride used for nausea and vomiting due to chemotherapy in patients with gynecological malignant tumors, with an additional study of the efficacy of different regimens. The subjects were 9 patients in whom 16 courses of CAP therapy were given (groupA) and 13 patients in whom 24 courses of modified CAP therapy were given (groupB). Granisetron hydrochloride 3mg/body was administered by intravenous drip in the two groups before chemotherapy. Clinical symptoms of nausea, vomiting, and anorexia were adminstered in oder to evaluate its efficacy. The percentage of patients who responded as"effective"or better was 90.0%. In different regimens, the efficacy was 93.8% in group A and 87.5% in group B. These results indicated clinically high usefulness in both groups. No side effects related to granisetron hydrochloride were found in this study.
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