冠動・静脈心房枝の血流パターンの解析

概要

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We analyzed phasic blood velocities in small arteries and veins of the left atrium by using laser Doppler velocimetry. In anesthetized open-chest dogs, the left atrial appendage was gently displaced to observe small branches of the artery and vein (150-500 μm, outer diameter). The tip of the fiber-optic was fixed on the vessel surface with a drop of cyanoacrylate, and the blood flow velocity was measured through the wall. Phasic blood velocity waveform in atrial coronary artery showed a systolic predominant pattern which resembled the aortic pressure waveform, but was characterized by a pronounced "dip" during atrial contraction period. Administration of isoproterenol resulted in an increase in the acceleration rate and an appearance of reverse flow during atrial contraction phase. Typical vein velocity pattern showed a major peak flow during atrial contraction phase, accompanied by relatively small flow during atrial diastole. Isoproterenol increased the acceleration rate of forward flow. These results indicate that blood velocity waveforms of artery and vein of the atrium are quite different from those of the ventricle. The phase opposition between arterial inflow into and venous outflow from the atrial myocardium indicates that a large portion of the inflow is stored in the capacitance vessels during atrial diastole and myocardial contraction promotes venous outflow.
特定非営利活動法人日本バイオレオロジー学会の論文