照射動脈管による実験的頸部動脈血行再建術 (続報)

概要

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Experimental studies were performed to research into the possibility of clinical application of arterial grafts transplantation irradiated with high voltage cathode ray.<BR>Homologous and heterologous arterial segments were implanted in Fisher rat back subcutaneously. Antibody titer of Fisher rat after implantation was measured with immune-adherence hemagglutination method. Antibody titer after implantation of homologous and heterologous grafts decreased to 1/8 by 2 millions rads irradiation. Antibody titer of irradiated heterologous graft was still higher than that of nonirradiated homologous one.<BR>To assess whether the postmortem change of arterial graft may affect its patency rate, homologous grafts taken from the corpses 3 or 6 hours after sacrifice, which were irradiated with 2 millions rads were transplanted in carotid artery in dogs using end-to-end anastomosis. Angiography 1 or 2 weeks after transplantation revealed the patency of all grafts of 14 dogs. On histological examination, 6 months after transplantation the structures of the graft, especially elastic fibers were well preserved. Complete reendothelialization was found on scanning electron microscope.<BR>It is concluded that homologous grafts obtained within 6 hours after death are useful and tolerate to construct extracranial-intracranial bypass by use of high voltage cathode ray irradiation.
The Japanese Society on Surgery for Cerebral Strokeの論文