Immunohistochemical and Ultrastructural Analyses of Cytoplasmic Blood Plasma Inclusions of Rat Hepatocytes
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, we investigated the histological, immunohistochemical and ultrastructural characteristics of cytoplasmic blood plasma inclusions that spontaneously occurred in a rat liver. Histologically, a number of cytoplasmic inclusions were observed in the liver of an 8-week-old female SD rat. These inclusions were strongly positive for PAS staining and resistant to diastase digestion. Immunohistochemical analyses revealed that these inclusions were positive for albumin and IgG; however, most of them were negative for LAMP-1 and LAMP-2. Ultrastructurally, the inclusions were surrounded by limiting membranes and composed of moderately electron dense, homogenous materials. These characteristics described here represent valuable information for pathological examination in toxicity studies.
- 日本毒性病理学会の論文
著者
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Michimae Yoshiko
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Koujitani Takatoshi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Kouchi Mami
Safety Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Seki Takaki
Safety Res. Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Toyosawa Kaoru
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Funabashi Hitoshi
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Tochitani Tomoaki
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Matsumoto Izumi
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Funabashi Hitoshi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Koujitani Takatoshi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Tochitani Tomoaki
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Toyosawa Kaoru
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Kouchi Mami
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Seki Takaki
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Michimae Yoshiko
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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- Immunohistochemical and Ultrastructural Analyses of Cytoplasmic Blood Plasma Inclusions of Rat Hepatocytes
- Immunohistochemical and Ultrastructural Analyses of Cytoplasmic Blood Plasma Inclusions of Rat Hepatocytes