Application of Prohibitin Immunohistochemistry to Rat Livers Treated with Methapyrilene Hydrochloride
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概要
- 論文の詳細を見る
An immunohistochemical staining method for prohibitin, a 30-kDa protein located in the inner membrane of mitochondria, is used for detection of mitochondria on formalin-fixed paraffin-embedded sections. Methapyrilene hydrochloride (MP), which is known to increase mitochondria in periportal hepatocytes, was administered once by oral gavage to male rats at a dose of 100 mg/kg. Hypertrophy with eosinophilic granules was noted in the periportal hepatocytes treated with MP. Immunohistochemical staining with prohibitin antibody demonstrated a positive reaction to eosinophilic granules. Electron microscopy showed an increased number of mitochondria in the periportal hepatocytes treated with MP compared to the control. Although electron microscopy is a useful tool to detect ultrastructural changes, an immunohistochemical examination with anti-prohibitin antibody is a simple and easy method for detecting cytoplasmic mitochondria quantitatively.
- 日本毒性病理学会の論文
- 2008-06-30
著者
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Koujitani Takatoshi
大日本住友製薬安全性研究所
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Koujitani Takatoshi
Department Of Toxicology And Teratology Developmental Research Laboratories Dainippon Pharmaceutical
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Seki Takaki
Safety Research Laboratories, Dainippon Sumitomo Pharma. Co., Ltd.
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Michimae Yoshiko
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Toyosawa Kaoru
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Matsumoto Izumi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Kouchi Mami
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Koujitani Takatoshi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Inoue Tadashi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Tanaka K
Department Of Gastroenterological Surgery Yokohama City University Graduate School Of Medicine
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Kouchi Mami
大日本住友製薬安全性研究所
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Kouchi Mami
Safety Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Seki Takaki
Safety Res. Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Toyosawa K
大日本住友製薬安全性研究所
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Toyosawa Kaoru
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Mikami Shinichi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Tanaka K
Department Of Gastrointestinal And Pediatric Surgery Division Of Reparative Medicine Institute Of Li
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Tanaka Kouji
Department Of Gastrointestinal And Pediatric Surgery Mie University Graduate School Of Medicine
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Inoue Tadashi
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Mikami Shinichi
Animal Health Products Dainippon Sumitomo Pharma Co. Ltd.
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Matsumoto Izumi
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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