Cystic Cholangioma in the Thoracic Cavity of a Rat
スポンサーリンク
概要
- 論文の詳細を見る
A female congenic rat produced by repeated backcrossing of Nihon rats, a model for hereditary renal cell carcinoma, to Brown Norway rats was necropsied at 24 months of age. At necropsy, a white mass about 1 centimeter in size was observed in the thoracic cavity, and the mass partly adhered to the esophagus and the diaphragm. Histologically, the mass was clearly circumscribed by connective tissue, and consisted of neoplastic cuboidal epithelial cells that showed cystic tubular proliferation. Some islands of well-differentiated hepatocytes and some vessels were observed in the mass. Immunohistochemically, the tumor cells were strongly positive for cytokeratin and partly positive for vimentin but were negative for mesothelin and Von Willebrand Factor. The positive rate for Ki-67 was 2.4%. Based on these histological and immunohistochemical evidences, we diagnosed this tumor as a cystic cholangioma that might have arisen from the ectopic hepatic tissue in the thoracic cavity.
- 日本毒性病理学会の論文
著者
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Michimae Yoshiko
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Okimoto Kazuo
Research Administration, Dainippon Sumitomo Pharma Co., Ltd.
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Matsumoto Izumi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Koujitani Takatoshi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Kouchi Mami
Safety Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Seki Takaki
Safety Res. Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Toyosawa Kaoru
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Funabashi Hitoshi
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Tochitani Tomoaki
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
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Matsumoto Izumi
Safety Research Laboratories Dainippon Sumitomo Pharma Co. Ltd.
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Okimoto Kazuo
Research Administration, Dainippon Sumitomo Pharma Co., Ltd., 33-94 Enoki-cho, Suita, Osaka 564-0053, Japan
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Koujitani Takatoshi
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Tochitani Tomoaki
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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Toyosawa Kaoru
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan
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