Therapeutic Potential of Canine Bone Marrow Stromal Cells (BMSCs) in the Carbon Tetrachloride (CCl4) Induced Chronic Liver Dysfunction Mouse Model
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概要
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Regenerative medicine using bone marrow cells is an attractive therapy for the cure of patients with severe liver disease. Here, we show the therapeutic potential of canine bone marrow stromal cells (BMSCs) in mouse models of CCl4-induced chronic liver dysfunction. We used two different models for xenotransplantation, nude mice and cyclosporine A (CSA) immunosuppressed mice. Serum parameters from a standard liver panel were not improved following transplantation. However, fibrotic liver lesions with severe inflammation were decreased in CCl4-treated CSA mice following BMSC transplantation. Effective migration of transplanted canine BMSCs was limited to persistently injured liver in CCl4-treated CSA mice, where they may be effective in resolving inflammatory fibrotic lesions. These results suggest that canine BMSCs are an effective cell source for liver regeneration.
著者
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Terai Shuji
Department Of Gastroenterology & Hepatology Yamaguchi University School Of Medicine
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Taura Yasuho
Department Of Veterinary Hospital Faculty Of Agriculture Yamaguchi University
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Sakaida Isao
Department Of Gastroenterology & Hepatology School Of Medicine Yamaguchi University
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Tani Kenji
Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences The Unive
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Nakazawa Hiroshi
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Yamamoto Naoki
Department Of Bioinformatics Faculty Of Engineering Soka University
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TERAI Shuji
Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
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ODA Yasutaka
Department of Veterinary Surgery Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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SAKAIDA Isao
Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
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YAMAMOTO Naoki
Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
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HARAGUCHI Tomoya
Department of Veterinary Surgery Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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TAKAGISHI Ryo
Department of Veterinary Surgery Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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ITAMOTO Kazuhito
Animal Medical Center, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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