Matrix Metalloproteinases (MMPs) Activity in Cultured Canine Bone Marrow Stromal Cells (BMSCs)
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概要
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Autologous bone marrow stromal cells (BMSCs) infusion therapy improves the hepatic fibrosis. To investigate the mechanism of remission, we evaluated the matrix metalloproteinase (MMP)-2 and -9 activity in canine BMSCs and the effect of pro-inflammatory cytokines on their expression. The activity and the gene expression of MMPs were analyzed by gelatin zymography and quantitative RT-PCR, respectively. The specific gelatinase bands were indicative effect of MMP-2 and -9 in canine BMSCs. MMP-2 expression seemed to be increased by TNF-α and IL-1β while MMP-9 was enhanced by TNF-α and IL-6. These results suggested that remissive effect on liver fibrosis might be partly attributable to the MMP-2 and -9 activity in BMSCs under the inflammatory condition.
著者
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Terai Shuji
Department Of Gastroenterology & Hepatology Yamaguchi University School Of Medicine
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Taura Yasuho
Department Of Veterinary Hospital Faculty Of Agriculture Yamaguchi University
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Sakaida Isao
Department Of Gastroenterology & Hepatology School Of Medicine Yamaguchi University
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Tani Kenji
Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences The Unive
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Nakazawa Hiroshi
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Yamamoto Naoki
Department Of Bioinformatics Faculty Of Engineering Soka University
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ODA Yasutaka
Department of Veterinary Surgery Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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HARAGUCHI Tomoya
Department of Veterinary Surgery Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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ITAMOTO Kazuhito
Department of Animal Medical Center, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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KOGA Masato
Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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TANI Kenji
Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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NAKAZAWA Hiroshi
Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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YAMAMOTO Naoki
Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan
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SAKAIDA Isao
Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan
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ODA Yasutaka
Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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