Photoinduced Upregulation of Calcitonin Gene-Related Peptide in A549 Cells through HNO Release from a Hydrophilic Photocontrollable HNO Donor
スポンサーリンク
概要
- 論文の詳細を見る
Nitroxyl (HNO), a one-electron-reduced form of nitric oxide, has various biological activities, including a cardioprotective effect. Here, we first synthesized another, more hydrophilic photocontrollable HNO donor (3), which can release HNO in a spatially and temporally controlled manner, and then examined the properties of our series of compounds as practical HNO donors in a cellular system under photocontrol. We selected compound 2 as the preferred donor, and used it to show that calcitonin gene-related peptide (CGRP) can be upregulated in A549 cells via photocontrolled HNO release. This result demonstrates the suitability of this photocontrollable HNO donor for biological investigations.
著者
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Nakagawa Hidehiko
Department Of Laboratory Medicine Miyazaki Medical College
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Miyata Naoki
Department Of Bioorganic And Medicinal Chemistry Faculty Of Pharmaceutical Sciences University Of To
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Adachi Yusuke
Department Of Analytical And Bioinorganic Chemistry Kyoto Pharmaceutical University
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Suzuki Takayoshi
Department Of Bioresource Environment Faculty Of Bioresource Sciences Akita Prefectural University
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Miyata Naoki
Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Tsumoto Hiroki
Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Matsuo Kazuya
Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Kameda Eri
Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Aizawa Kazuyuki
Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University
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