An Efficient Synthesis of a Potent Anti-inflammatory Agent, Viscolin, and Its Inducible Nitric Oxide Synthase Inhibitory Activity

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概要

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• A new and efficient synthetic pathway employed the aldol condensation between the acetophenone (3) and vanillin derivative (4) resulted in the precursor chalcone intermediate (14). The target compound viscolin (1) could be afforded through the hydrogenation of the chalcone and followed by deprotection. The present strategy described the development of a more efficient procedure that allowed large-scale production of viscolin for the further research of biological activity both in vitro and in vivo.

• 公益社団法人　日本薬学会の論文

著者

• Wu Tian-shung

  Department Of Applied Chemistry Providence College Of Arts And Science

• Kuo Ping-chung

  Department Of Biotechnology National Formosa University

• Leu Yann-lii

  Graduate Institute Of Natural Products Chang Gung University

• Yang Mei-Lin

  Department of Chemistry, National Cheng Kung University

• Chen Yi-Hsien

  Department of Chemistry, National Cheng Kung University

• Huang Chieh-Hung

  Department of Chemistry, National Cheng Kung University

• Liao Yu-Ren

  Department of Chemistry, National Cheng Kung University

• Lee E-Jian

  Neurophysiology Laboratory, Neurosurgical Service, Departments of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University Medical Center and Medical School

• Kuo Ping-Chung

  Department of Biotechnology, National Formosa University

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