Essential Oils from Sweet Basil (Ocimum basilicum) as Novel Enhancers to Accelerate Transdermal Drug Delivery(Biopharmacy)
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概要
- 論文の詳細を見る
The purpose of this study was to evaluate the essential oils from sweet basil (Ocimum basilicum, OB) as skin permeation enhancers to promote the percutaneous absorption of drugs. The in vitro and in vivo irritancy of the essential oils was also examined. Terpenes with various carbon numbers (mono-, sesqui-, di-, and tri-) were identified in both the lower-polarity fraction (OB-1) and higher-polarity fraction (OB-2). In vitro skin permeation and deposition of indomethacin were significantly enhanced after treatment with OB essential oils. The enhancing effect of OB-1 was greater than that of OB-2 in the in vitro permeation and in vivo cutaneous microdialysis analyses as well as in the plasma concentration of indomethacin. On the other hand, the in vivo study showed that OB-2 had a greater ability to retain the drug within the skin than did OB-1. Enhancement of the skin permeation of drugs by OB essential oils might be mainly due to improvement in the partitioning of the drugs to the stratum corneum. Both in vitro cell cultures (keratinocytes and skin fibroblasts) and in vivo transepidermal water loss showed no or only negligible irritation to skin by OB essential oils.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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HWANG Tsong-Long
Graduate Institute of Natural Products, Chang Gung University
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Hwang Tsong-long
Graduate Inst. Of Natural Products Chang Gung Univ.
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Hwang T‐l
Graduate Institute Of Natural Products Chang Gung University
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Leu Y‐l
Graduate Institute Of Natural Products Chang Gung University
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Leu Yann-lii
Graduate Institute Of Natural Products College Of Medicine Chang Gung University
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Fang Jia-you
Graduate Institute Of Natural Products Chang Gung University
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CHENG Hsiao-Chin
Graduate Institute of Natural Products, Chang Gung University
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Cheng Hsiao-chin
Graduate Institute Of Natural Products Chang Gung University
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Leu Yann-lii
Graduate Institute Of Natural Products Chang Gung University
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