(−)-Hydroxylindestrenolide, a New Sesquiterpenoid from a Gorgonian Coral Menella sp. (Plexauridae)

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概要

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• (−)-Hydroxylindestrenolide (1), an enantiomer of the known sesquiterpenoid, (+)-hydroxylindestrenolide (2), was isolated from a gorgonian coral identified as Menella sp. The structure, including the relative stereochemistry of 1 was established by spectroscopic methods and by comparison the spectral and physical data with those of 2. Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 μg/ml by human neutrophils.

著者

• Chen Yu-pei

  Taiwan Coral Res. Center (tcrc) National Museum Of Marine Biology & Aquarium (nmmba) And Graduat

• Sheu Jyh-horng

  Department Of Biological Science And Technology Meiho Institute Of Technology

• HWANG Tsong-Long

  Graduate Institute of Natural Products, Chang Gung University

• Sheu J‐h

  National Sun Yat‐sen Univ. Kaoshiung Twn

• Wen Zhi-hong

  Department Of Marine Biotechnology And Resources National Sun Yat-sen University

• Chen Yung-Husan

  National Museum of Marine Biology and Aquarium

• Hwang Tsong-long

  Graduate Inst. Of Natural Products Chang Gung Univ.

• Wang Wei-hsien

  National Museum Of Marine Biology & Aquarium (nmmba)

• Sung Ping-jyun

  Graduate Inst. Of Marine Biotechnology National Dong Hwa Univ.

• Kuo Yueh-Hsiung

  Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University

• Chen Yu-pei

  Taiwan Coral Research Center (tcrc) National Museum Of Marine Biology & Aquarium (nmmba) And Gra

• Lu Mei-chin

  Graduate Inst. Of Marine Biotechnology National Dong Hwa Univ.

• Kao Shih-Yao

  Graduate Institute of Marine Biotechnology, National Dong Hwa University

• Chang Yu-Chia

  National Museum of Marine Biology and Aquarium, Taiwan

• Su Jui-Hsin

  Graduate Institute of Marine Biotechnology, National Dong Hwa University

• KUO Yueh-Hsiung

  Tsuzuki Institute for Traditional Medicine, China Medical University

• Lu Mei-Chin

  Graduate Institute of Marine Biotechnology, National Dong Hwa University

• Sung Ping-Jyun

  Graduate Institute of Marine Biotechnology, National Dong Hwa University

• Chen Yung-Husan

  National Museum of Marine Biology & Aquarium (NMMBA)

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