Cytotoxic Monocarbocyclic Sesterterpenoids from a Marine Sponge Luffariella sp.

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概要

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• Six new monocarbocyclic sesterterpenoids, luffalides A–F (1–6), together with four known sesterterpenes (7–10), were isolated from a marine sponge Luffariella sp. The structures of compounds 1–6 were elucidated on the basis of spectroscopic data analysis (NMR and CD) and comparison of the spectroscopic data with those of known analogues. Among these new metabolites, compounds 1–5 are rarely found in monocarbocyclic sesterterpenoids possessing an 1-isopropenyl-2-methylcyclopentane ring system. Evaluation of the cytotoxicities showed that compound 10 exhibited significant cytotoxicity against HL-60, MOLT-4 and K-562 cell lines, with IC50 values of 0.54, 0.32 and 0.96 μM, respectively. Moreover, compound 9 also showed significant HL-60 and MOLT-4 inhibitory activity, with IC50 values of 1.87 and 1.13 μM.

• 公益社団法人 日本化学会の論文

著者

• Lu Mei-chin

  Graduate Inst. Of Marine Biotechnology National Dong Hwa Univ.

• Wu Yu-Jen

  Department of Beauty Science, Meiho University

• Su Jui-Hsin

  Graduate Institute of Marine Biology, National Dong Hwa University

• Su Tzu-Rong

  Department of Beauty Science, Meiho University

• Liao Zuo-Jian

  Graduate Institute of Marine Biology, National Dong Hwa University

• Lu Mei-Chin

  Graduate Institute of Marine Biology, National Dong Hwa University

関連論文

• (−)-Hydroxylindestrenolide, a New Sesquiterpenoid from a Gorgonian Coral Menella sp. (Plexauridae)
• Cladielloides C and D : Novel Eunicellin-Based Diterpenoids from an Indonesian Octocoral Cladiella sp.
• Cytotoxic polyacetylenes from a Formosan marine sponge Callyspongia sp.
• Cytotoxic Monocarbocyclic Sesterterpenoids from a Marine Sponge Luffariella sp.

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