Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells
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概要
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Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.
著者
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Chang Chi-I
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Chen Chiy-Rong
Department of Biological Science and Technology, Meiho Institute of Technology
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Liao Yun-Wen
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Shih Wen-Ling
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Cheng Hsueh-Ling
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Chang Chi-i
Graduate Inst. Of Biotechnology National Pingtung Univ. Of Sci. And Technol.
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Chen Chiy-rong
Department Of Biological Science And Technology Meiho Institute Of Technology
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Wang Lai
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Kuo Yueh-Hsiung
Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University
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Liu Hung-Jen
Institute of Molecular Biology, National Chung-Hsing University
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KUO Yueh-Hsiung
Tsuzuki Institute for Traditional Medicine, China Medical University
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Chen Chiy-Rong
Department of Biological Science and Technology, Meiho University
関連論文
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