D:C-Friedooleanane-Type Triterpenoids from Lagenaria siceraria and Their Cytotoxic Activity
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概要
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Four new D:C-friedooleanane-type triterpenes, 3β-O-(E)-feruloyl-D:C-friedooleana-7,9(11)-dien-29-ol (1), 3β-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-ol (2), 3β-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-oic acid (3), and methyl 2β,3β-dihydroxy-D:C-friedoolean-8-en-29-oate (6), together with five known triterpenes with the same skeleton, 3-epikarounidiol (4), 3-oxo-D:C-friedoolena-7,9(11)-dien-29-oic acid (5), bryonolol (7), bryononic acid (8), and 20-epibryonolic acid (9), were isolated from the methanol extract of the stems of Lagenaria siceraria. The structures of those compounds were elucidated using spectroscopic methods. Compounds 3 and 9 showed significant cytotoxic activity against the SK-Hep 1 cell line with IC_<50> values of 4.8 and 2.1μg/ml, respectively. Based on these initially promising results, the two D:C-friedooleanane triterpenes merit further study as potential anticancer agents.
- 公益社団法人日本薬学会の論文
- 2008-03-01
著者
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Chang Chi-I
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Chen Chiy-Rong
Department of Biological Science and Technology, Meiho Institute of Technology
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Chen Chiy-rong
Dep. Of Biological Sci. And Technol. Meiho Inst. Of Technol.
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Chang Chi-i
Graduate Inst. Of Biotechnology National Pingtung Univ. Of Sci. And Technol.
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CHEN Hung-Wei
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology
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Chen Hung-wei
Graduate Institute Of Biotechnology National Pingtung University Of Science And Technology
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Chen Chiy-rong
Department Of Biological Science And Technology Meiho Institute Of Technology
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Chang Chi-i
Graduate Institute Of Biotechnology National Pingtung University Of Science And Technology
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