Phenanthrenoids from Juncus acutus L., New Natural Lipopolysaccharide-Inducible Nitric Oxide Synthase Inhibitors
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概要
- 論文の詳細を見る
The novel natural product juncutol (1), 1,4,7-trimethyl-8,9-dihydro-4H-cyclopenta[def]phenanthrene-2,6-diol, along with the three related metabolites juncusol (2), dehydrojuncusol (3), and 6-hydroxymethyl-1-methyl-5-vinyl-9,10-dihydrophenanthrene-2-oI(4), were isolated from the rhizomes of Juncus acutus L. (Juncaceae) growing in Egypt. The structural identity of 1 was determined on the basis of spectroscopic analyses, including 2D NMR spectroscopy. The inhibitory effect of these natural products on the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide-stimulated RAW264.7 macrophage cells was determined for the first time. The unprecedented symmetrical compound juncutol (1) was found to be the most potent inhibitor against the induction of the proinflammatory iNOS protein.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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Wen Zhi-Hong
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
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Sheu Jyh-Horng
Department of Marine Biotechnology and Resources, National Sun Yat-sen University
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Amer Mohamed
Department of Obstetrics and Gynecology, Ain Shams University
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Sheu Jyh-horng
Department Of Biological Science And Technology Meiho Institute Of Technology
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Amer Mohamed
Department Of Obstetrics And Gynecology Ain Shams University
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Amer Mohamed
Department Of Pharmacognosy Faculty Of Pharmacy Mansoura University
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AHMED Atallah
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University
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Sheu Jyh-horng
Department Of Marine Biotechnology And Resources National Sun Yat-sen University
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BEHERY Fathi
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University
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NAEEM Zain
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University
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MAATOOQ Galal
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University
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Wen Zhi-hong
Dep. Of Marine Biotechnology And Resources National Sun Yat-sen Univ.
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Wen Zhi-hong
Department Of Marine Biotechnology And Resources National Sun Yat-sen University
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Maatooq Galal
Department Of Pharmacognosy Faculty Of Pharmacy Mansoura University
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Naeem Zain
Department Of Pharmacognosy Faculty Of Pharmacy Mansoura University
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Behery Fathi
Department Of Pharmacognosy Faculty Of Pharmacy Mansoura University
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Ahmed Atallah
Department Of Marine Biotechnology And Resources National Sun Yat-sen University
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