Preparation of a Series of Novel Bichalcones Linked with a 1,4-Dimethylenepiperazine Moiety and Examination of Their Cytotoxicity

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概要

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• The chalcone basic skeleton is a unique template which is associated with widespread biological activities. In the present study, a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety was prepared through Mannich reaction and Clasien–Schmidt condensation. The synthetic analogs 2—16 were subjected into the cytotoxicity examinations using a panel of 25 human tumor cell lines. Among the tested compounds, 3 and 4 which possessed the 3-pyridyl and phenyl groups as the substructure, respectively, displayed significant cytotoxicity against all the tumor cell lines. The results suggested that these bichalcones were potential to be the anticancer lead drugs.

• 公益社団法人　日本薬学会の論文

著者

• Wu Tian-shung

  Department Of Applied Chemistry Providence College Of Arts And Science

• Kuo Ping-chung

  Department Of Biotechnology National Formosa University

• Chan Hsiu-hui

  Chinese Medicinal Res. And Dev. Center China Medical Univ. And Hospital

• Lin Meng-Liang

  Department of Medical Laboratory Science and Biotechnology, China Medical University

• Reddy Mopuru

  Department of Chemistry, National Cheng Kung University

• Chen Shih-Shun

  Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology

• Chan Hsiu-Hui

  Chinese Medicinal Research and Development Center, China Medical University and Hospital

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