The Constituents and Their Bioactivities of Houttuynia cordata
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概要
- 論文の詳細を見る
Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-β-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 μM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 μM.
- 公益社団法人 日本薬学会の論文
著者
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Wu Tian-shung
Department Of Applied Chemistry Providence College Of Arts And Science
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SU Chung-Ren
Department of Chemistry, National Cheng Kung University
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Chou Shu-Chen
Department of Chemistry, National Cheng Kung University
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Ku Yuh-Chi
Department of Life Science, Fu-Jen University
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Wu Tian-Shung
Department of Chemistry, National Cheng Kung University
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