蓚酸カルシウム結石患者における尿中遊離アミノ酸の排泄動態について〔英文〕

概要

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A comparison was made on the excretion levels and pattern of free amino acids between 19 patients with upper urinary stone (14 men and 5 women), who revealed that their stones contained more than 90 % of calcium oxalate by means of infrared spectroanalysis, and 47 normal controls (30 men and 17 women) . Both male and female patients of calcium oxalate stone group showed to tendencies of the amount of excetion and excretion pattern of neutral amino acids, especially glycine, toward decreased, and taurine toward increased. Since these tendencies were almost same as the result obtained from division of the amount of each amino acid by 24h. C. cr., especially in the female patients, it was suggested that these changes in the calcium oxalate stone formers might be occured not by renal demages but by metabolic disorders of amino acid on kidney or liver.