Onjisaponin Bの免疫グロブリン産生系に及ぼす影響
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The plaque technique of Cunningham and Szenberg was used to study the adjuvant effect of purified onjisaponin B on IgM and IgG formation.<BR>1) The administration of onjisaponin B caused a significant increase of the number of plaque forming cells of the spleen after immunization with sheep red blood cells (SRBC) .<BR>2) The highest adjuvant effect was obtained by a dose of 0.01μg/mouse.<BR>3) Time intervals between onjisaponin B and antigen injections revealed that onjisaponin B showed the most obvious adjuvant effect when injected with onjisaponin B and antigen simultaneously.<BR>4) Onjisaponin B showed a remarkable adjuvant effect when injected by the intraperitoneal or intramuscular route, but less by the intravenous or subcutaneous route.<BR>5) The administration of onjisaponin B increased not only IgM antibody forming cells, but also IgG antibody forming cells. The number of these cells reached the peak 4 and 6 days after the injection of antigen, respectively.<BR>Passive cutaneous anaphylaxis (PCA) was used to study adjuvant effect of onjisaponin B on IgE antibody formation in mouse after immunization with ovalbumim.<BR>6) IgE antibody formation was not observed at all when albumim was injected alone.<BR>7) Adjuvant effect of onjisaponin B was not observed when injected with 1 and 10 μg of onjisaponin B and 100 μg of antigen. A little amount of transient antibody was observed in the case of injecting 1000μg of antigen.<BR>8) Striking adjuvant effect was observed in the case of Al (OH) <SUB>3</SUB> gel. When onjisaponin B was added to Al (OH) <SUB>3</SUB> gel as adjuvant, no remarkable change in the production of IgE was recognized as compared with Al (OH) <SUB>3</SUB> gel alone.
- 学校法人 昭和大学・昭和医学会の論文
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