マウス遅延型皮膚反応に及ぼすSchizophyllanと諸種制癌剤の影響

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The influences of schizophyllan (SPG) and various kinds of antitumor agents on the delayed cutaneous hypersensitivity test with picryl chloride were examined. 1. Influence of alkylating agents : Among cyclophosphamide, carboquone and thio-TEPA, cyclophosphamide and carboquone inhibited delayed-type hypersensitivity (DTH) . The inhibition could not be recovered by treatment with SPG. 2. Antimetabolites : Among cyclocytidine, cytosine arabinoside, methotrexate, 6-mercaptopurine, azathioprine, 5-fluorouracil and futraful, methotrexate, 6-mercaptopurine, 5-fluorouricil and futraful inhibited DTH. The inhibition showed tendency towards recovery by the administration of SPG. 3. Antibiotics : Among adriamycin, actinomycin D, chromomycin A3, bleomycin and mitomycin C, only mitomycin C inhibited DTH. Inhibition could be recovered to normal levels by treatment with SPG. Bleomycin appears to stimulate DTH. 4. Alkaloids : No inhibition was observed in the cases of vinblastine and vincristine. Vincristine seemed to enhance DTH. 5. Steroid hormones : No influence was observed when cortisone, prednisolone and dexamethasone were administered. 6. Enzyme : L-Asparaginase showed no effect on DTH. 7. Immunopotentiating agent : Krestin enhanced DTH by intraperitoneal injection at a much higher dose (200 mg/kg) than that of SPG (2 mg/kg) .
学校法人昭和大学・昭和医学会の論文