腸内細菌の粘液型変異菌に及ぼすNa2So3の抗菌作用-2-腸内細菌のムタビール型変異(村瀬)菌より生じた粘液型菌に及ぼす発育阻止作用の分析
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Mucoid variant mutated from Mutabile-type Var. (Murase) or mucoid RT mutated from the mucoid variant are inhibited in their growth upon the plating on to the 0.5-1.0 % Na<SUB>2</SUB>SO<SUB>3</SUB> agar. However, no inhibition is observed when the non-mucoid one such as Mutabile-type Var., and its so-called back mutant, the RT. are plated. Also, same tendency is seen in case of mucoid var. mutated from the original type of Salmonella or Escherichia and the resistant strains of mucoid RT of them.<BR>Inhibition phenomenon is always observed when the organisms are cultured on the Na<SUB>2</SUB>SO<SUB>3</SUB> agar plate or kept in the Na<SUB>2</SUB>SO<SUB>3</SUB> saline or broth in the incubator at 37°C but not in the refrigerator.<BR>If the paper disc method is employed and the plate is kept in the refrigerator over night before incubation at 37°C, no inhibition zone could be proved because of too diluted diffusion of Na<SUB>2</SUB>SO<SUB>3</SUB>.<BR>The activity of Na<SUB>2</SUB>SO<SUB>3</SUB> is thought to be dependent to the weak bactericidal power of the compound. Its activity is resistant to the autoclaving (15 lb 20') or Koch's sterilization (100°C 30' 3x) .<BR>The Na<SUB>2</SUB>SO<SUB>3</SUB> agar plate may be active over 3 weeks when it is preserved anaerobically. Na<SUB>2</SUB>SO<SUB>3</SUB> obtained from the newly opened bottle is more active than that of the old one.<BR>The Na<SUB>2</SUB>SO<SUB>3</SUB> loose its activity in accordance with the loss of fuchsinreducing power.<BR>The antibacterial activities are examined on Na<SUB>2</SUB>SO<SUB>3</SUB> and its derivates. No activity was found on Na<SUB>2</SUB>SO<SUB>4</SUB>. Na<SUB>2</SUB>S<SUB>2</SUB>O<SUB>3</SUB> showed rather milder activity than that of Na<SUB>2</SUB>SO<SUB>3</SUB> and NaHSO<SUB>3</SUB> was the most active both to mucoid varr. and non-mucoid vary. No selective action was observed<BR>PH of the Na<SUB>2</SUB>SO<SUB>3</SUB> and its derivates has no effect against the activity specifically. But, when the PH of NaHSO<SUB>3</SUB> is adjusted to that of Na<SUB>2</SUB>SO<SUB>3</SUB>, the activity is rather lowered and permits the growth of some mucoid variant colonies, even no growth is allowed in the former concentration. Therefore it is believed that the activity of Na<SUB>2</SUB>SO<SUB>3</SUB> against our two kinds of strains of mucoid varr. means the weak bactericidal and bacteriostatic power in relation to the reducing power of the compound. To clarify the selective action of Na<SUB>2</SUB>SO<SUB>3</SUB> on the mucoid varr. further investigations should be performed.
- 学校法人 昭和大学・昭和医学会の論文
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