乳癌患者の色素単独法(インジゴカルミン)によるセンチネルリンパ節生検--第二外科の成績

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The sentinel node (SN), defined as the first draining node from the primary lesion, has proven to be a good indicator of the metastatic status of regional lymph nodes in solid tumors. This procedure is a promising surgical technique to avoid unnecessary axillary lymph node dissection (ALND) in breast cancer. If ALND can be omitted, patients avoid suffering from edema and disorders of the postoperative arm. Thus, we strongly believe that SNB would be a convenient and safe procedure to minimize the operative complications of breast cancer surgery. We reviewed 129 patients with breast cancer who had received SNB using the“indigocarmine single method”and a concurrent backup ALND operation in the Department of Surgery, School of Medicine, Showa University from December, 2001 to March, 2005. The identification rate of SNB and its relevance to age, diameter of tumor, main locus of tumor, and pathological type were evaluated. The identification rate of SNB was 85.3% of 110 cases and 91.4% of 63 cases after 2004. Only papillotubular carcinoma showed a high identification rate of SNB when identification rate and age, diameter of tumor, main locus of tumor and pathological type were compared to identification rate of SNB. The proper diagnosis rate in SNB was 91.9%, which was similar to other reports. However, a false negative rate of SNB was 38.5%. We attribute the high false negative rate of SNB to the insufficient number of sections of the SNB specimens and the lack of immunohistochemical examinations in SNB. Establishing SNB standards would serve the field of breast cancer surgery by minimizing postoperative complications.
学校法人昭和大学・昭和医学会の論文

乳癌患者の色素単独法(インジゴカルミン)によるセンチネルリンパ節生検--第二外科の成績

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