浸潤性乳管癌n1症例における再発危険因子としての多剤耐性因子および組織学的異型度の検討

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On 60 cases of breast cancer with lymph node metastasis who received surgery in Showa University Hospital from 1994 to 1998, we investigated the relation of estrogen receptor (ER), Her-2, histological grade, multidrug resistance (MDR-1 MRP-1, MRP-2), MIB-1, topoiso melase- II, and recurrence retrospectively. On f ormalin-fixed paraffin-embedded sections, following antibody, ER, Her-2, MIB-1, MDR-1, MRP-1, MRP-2 were used for immunohistochemical staining. We investigated the recurrence value with clinical factors, MIB-1 labeling index, toppisomelase- II labeling index and expression of ER, Her-2, MRP-1. Immunohistochemically, 1.7% of cases were positive in MDR-1, 68.3% of cases were positive in MRP-1, 96.7% of cases were positive in MRP-2, respectively. An expression of MRP-1 and an increase of MIB-1 labeling index correlated with risk of recurrence. Therefore, MRP-1 was a good indicator to predict recurrence.
学校法人昭和大学・昭和医学会の論文