フラクトオリゴ糖の抗アレルギー効果--十二指腸病理組織学的検討

概要

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Background Recently, there has been a rapid increase in the number of patients with food allergies in Japan compared to Western countries. The mainstay of treatment in food allergies is still food avoidance ; however, medical treatment strategies aimed at protecting the gastrointestinal tract are being investigated. To determine the effect of fructooligosaccraide (FOS), a prebiotic, on small intestinal changes in a mouse model of food allergy as a new cure for food allergy. A mouse model of food allergy was performed by ovalbumin (it omits Following OVA) in 52 mice. Mice were randomly assigned to receive either FOS or placebo. Treatment was carried out for 2, 5 and 8weeks. The small intestinal changes were investigated by microscopy. The number of mast cells in the duodenum significantly increased after sensitization with OVA. The FOS-treated group was observed to have a significant decrease in the number of mast cells after 8 weeks of treatment. Moreover, the increase in villus edema noted after OVA-sensitization was prevented in the FOS-treated mice. FOS might be used as a treatment in food allergy treatment by protecting the gastrointestinal tract.
学校法人昭和大学・昭和医学会の論文