非ステロイド系消炎剤注射用Ketoprofenの口蓋扁桃摘出術後嚥下痛に対する効果--第2相臨床試験

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Clinical studies of non-steroidal anti-inflammatory, ketoprofen injectable, at doses of 25mg, 50mg, and 100mg have been carried out in Japanese adult patients who had undergone tonsillotomy, in order to assess the efficacy of the analgesic effect on pain when swallowing.As an active control, patients were given 50mg of ketoprofen orally.Regardless of doses administered, the analgesic effect was evident 5 to 15 minutes after intramuscular injection of ketoprofen, while effects seen with oral dosing were evident 30-60min. after the administration.In most cases, duration of effect varied from 5 to 12 hours in the group on the injectable form dose dependent, and from 4 to 6 hours in the group on the oral administration.Ketoprofen could be detected in the plasma at 5min. after i. m. administration and a maximum level was seen within 15min.The plasma concentration was proportionate to doses administered. After oral dosing, ketoprofen was detected in the plasma 30min. after administration and the maximum plasma concentration was attained during the first hour.
耳鼻咽喉科臨床学会の論文