Chicken上顎洞におけるNewcastle disease virusの防御機構 (三吉康郎教授開講20周年記念論文集)

概要

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The mechanism of resistance to the mesogenic Newcastle disease virus in the chicken maxillary sinus and turbinate was studied by intranasal inoculation.The lesions induced by the intranasally inoculated NDV-B were usually selective destruction of significant portions of the inner surface of the turbinate scroll, but sinus lesions though sometimes present in NDV infection were not common. These results were supported by the amount of the virus and the mucociliary transport time in the turbinate and sinus.The chicken maxillary sinus was infected with NDV-B by intrasinus inoculation. Although cessation of the mucociliary function was not observed after the application of 5% cocaine into the maxillary sinus, deceleration of the sinus clearance time after treatment was statistically significant. The virus was recovered from the chicken maxillary sinuses which were treated with 5% cocaine after 24 hours of intranasal NDV infection, and this is supported by histologic examination.From these results, it has been shown that the mucociliary activity in the maxillary sinus, especially in the sinus ostium, rather than the direction of the mucociliary flow, is one of the most important factors of protection against sinus infection.
耳鼻咽喉科臨床学会の論文