多発性硬化症の誘発耳音響反射および蝸電図

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A 24-year-old female with multiple sclerosis had right-sided hearing impairment with tinnitus. She underwent electrocochleography (ECochG) and examination of evoked otoacoustic emission (EOAE) to assess cochlear function.An acoustic probe, type K-3, prepared to measure EOAEs was inserted into the external ear canal. ECochG-AP and CM were recorded by a transtympanic needle electrode technique. The CM and AP were recorded simultaneously and separated into their respective two channels in real time operation by the processor programmed for the isolation of the AP and CM. Short tone bursts were employed as acoustic stimulation to evoke both EOAEs and ECochG-CMs. Clicks and short tone bursts were used to measure ECochG-AP.Both fast and slow components of EOAEs appeared in either the period of deteriorated hearing acuity or when it was improved. They showed normal detection thresholds and input-output curves during both periods.ECochG-CMs with almost normal detection thresholds and input-output functions were obtained during the period of deteriorated hearing acuity. Delayed CMs with normal delay times and normal detection thresholds were observed during both periods.AP (N1) input-output curves during relapse with hearing loss were notably lower in amplitude and longer in latency than those obtained at the time hearing impairment showed improvement.The EOAE and ECochG findings suggested that this patient had almost normal cochlear function, and we assumed from the MRI and ABR findings as well as the ECochG that the hearing impairment was caused by dysfunction of auditory pathways . in the brainstem, including involvement of AP (N1) levels.
耳鼻咽喉科臨床学会の論文

多発性硬化症の誘発耳音響反射および蝸電図

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