Effect of Lipo-Prostaglandin E1 on Sudden Deafness

概要

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In this study we examined 310 patients with sudden deafness treated in our hospital between 1996 and 2001. Seventy-one patients were treated with steroid only (steroid group), 130 patients were treated with steroid and Lipo-PGE1 combined therapy (steroid-LipoPGE1 group) and 53 patients were treated with Lipo-PGE1 only (LipoPGE1 group).The improvement rate was 39.4, 67.7 and 81.1% in the steroid, steroid-LipoPGE1 and LipoPGE1 groups, respectively. The improvement rate was significantly higher in the steroid-LipoPGE1 and LipoPGE1 groups than in the steroid group (p<0.01). No significant difference in improvement rate was noted between steroid-LipoPGE1 group and LipoPGE1 group (p<0.05).These results suggest that the improvement of blood flow in the inner ear may be very important and Lipo-PGE1 is effective in treating sudden deafness.
耳鼻咽喉科臨床学会の論文