Experimental otitis media with mucoid effusion. Eustachian tube dysfunction combined with immunosuppression.:-Eustachian Tube Dysfunction combined with Immunosuppression-

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Inflammation is now considered to be the main cause of otitis media with effusion. However, in experimental otitis media with effusion caused by secondary immune responses and iflammatory agents, the effusion is serous and temporary.We induced otitis media with mucoid effusion in cats by impairing their active ventilatory function and administering immunosuppressant drugs. To cats with eustachian tube dysfunction caused by removal of the tensor veli palatini muscle, we gave cyclosporin and cyclophosphamide. When negative pressure due to tubal dysfunction was caused in the middle ear, otitis media with mucoid effusion resulted in all cases. On the contrary, OME was not observed when the tympanogram remained Type-A.These results indicate that in the etiology of middle ear inflammation transtubal infection due to negative pressure caused by tubal ventilatory dysfunction is an important factor.
耳鼻咽喉科臨床学会の論文