Effect of Ketotifen on administration of nasal mucus cilium function.

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Ketotifen nasal spray was administered into the nostrils in experimental animals (rabbits) and man in order to investigate the effects on mucus cilium function. Test preparations used were Ketotifen nasal spray (0.1 mg/puff), placebo nasal spray and saline.In rabbits, there were no significant differences among the three groups as to trans-portation speed or beating frequency of the mucus cilia at the end of 1 and 4 weeks of continuous administration. The Ketotifen group displayed no pathohistological differences from the other two groups at the end of 4 weeks. In man, the transportation time of the nasal mucus cilia was determined by the saccharin method; no significant differences were observed among the three groups.Ketotifen nasal spray does not seem to influence nasal mucus cilium function in man or in rabbits.
耳鼻咽喉科臨床学会の論文