NFLXの慢性副鼻腔炎に対する効果

概要

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This study was designed to determine the effectiveness of norfloxacin (NFLX), a new quinolonecarboxylic acid analogue, on the symptoms and signs of chronic sinusitis. The subjects of this study were 14 patients aged 13 to 71 years, who received NFLX 600mg per day p. o. for 2 weeks. Neither antiinflammatory nor mucolytic agents were given.The effectiveness of NFLX on the subjective symptoms and rhinoscopic observations was 64.3%. X-ray opacity of the maxillary sinus was evaluated with a microdensitometer. The pre- and post- treatment data were compared in 13 patients (26 maxillary sinuses). Improvement of X-ray opacities by NFLX treatment was noted in 23.1 %. The general effectiveness of NFLX on the subjective symptoms, rhinoscopic observations and X-ray opacity was 65.4%. No side effects were noted.
耳鼻咽喉科臨床学会の論文