突発性難聴に対する抗ウイルス剤の点滴静注療法の検討

概要

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Viral infection seems to be the most common cause of sudden deafness. In the context, thinking that an antiviral agent might be effective against sudden deafness of unknown etiology. We used an antiviral agent, acyclovir, in addition to conventional palliative therapy, to treat 89 patients with sudden deafness of unknown etiology. They were divided into 3 groups, Group A received steroids and acyclovir, Group B acyclovir only, and Group C steroid only. The nonspecific treatments were the same in all three groups. Outpatients received 250mg of acyclovir by i. v, infusion for one hour per day for 7 days, and inpatients received 250mg every 8 hours for 7 days.Audiometric tests with standard pure sound were performed just before treatment and twice a week during treatment against Herpes simplex virus, Varicella zoster virus, Epstein-Barr virus, Cytomegalovirus and Mumps virus were determined.The effectiveness of the treatment was evaluated by the following parameters: auditory capacity before treatment, difference of therapeutic effect between inpatients and outpatients, vestibular symptoms, age and sex of patients, tinnitus, and stellate ganglion block. No significant improvement of auditory capacity was found in any of these parameters. We conclude that acyclovir is ineffective against sudden deafness. It seems more important to try to save the damaged cells than to suppress the growth of the virus.
耳鼻咽喉科臨床学会の論文