Endocochlear potential and action potential.

概要

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Many researchers on cochlear electrophysiology have noted that the decrease of endocochlear potential (EP) induces a decrease in the amplitude both in cochlear microphysics (CM) and in summating potential (SP) under the same acoustic stimulus. However, there have been few reports on the relationship between EP and cochlear action potential (AP).Using a microelectrode technique, we examined the records of EP and AP in guinea pigs and analysed the effect of EP on the response of both APs, one acquired from the cochlea surface and the other from inside the cochlea.During 3 minutes of apnea, the decrease of EP caused a decrease of amplitude in both APs (from the surface and from the inside). APs disappeared at 0mV of EP and were never observed when the EP was negative.Furosemide injection caused the same changes. These results indicate that only the positive component of EP contributes to the generation of AP in the cochlea.