Effect of Ca-Antagonist (Nifedipine) to Spinal Cord Ischemia. Preliminary report of intravenous injection.:Preliminary report of intravenous injection

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It has been reported that the neuronal death induced by spinal cord ischemia would be mediated by a calcium influx through Ca-channel. The aim of this experiment was to investigate the effect of Ca-antagonist (nifedipine) in spinal cord ischemia, indued by aortic crossclamping (AXC), using spinal evoked potential (spinal-EP) as an indicy. Firstly, we identified that infrarenal lumbar arteries would supply the blood-flow to lumbar part of spinal cord. On electrophysiological approach, We stimulated a pair of electrodes inserted into the disk of T12-13 and recorded from electrodes into the disk of L5-6. The time to spinal-EP loss was measured as a group of control (Group C), after infrarenal AXC. As a group of Ca-antagonist (Group N), nifedipine (30μg/kg bolus followed by 10μg/kg/min) was injected intravenously 30min before AXC. The time to potential loss was checked under AXC-induced cord ischemia. Group N showed 3min prolongation, compared with Group C.
西日本整形・災害外科学会の論文