過酸化水素,キサンチンオキシダ-ゼ反応系によるコイ赤血球の溶血とメトヘモグロビン生成〔英文〕

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In vitro hemolysis and methemoglobin formation in common carp erythrocytes were investigated using hydrogen peroxide and a hypoxanthine-xanthine oxidase reaction. Hemolysis was found to be induced at H2O2 concentrations of more than 2.3mM, which is much lower than the concentration reported in mammals. Remarkable methemoglobin formation was also induced by H2O2. Cat-alase was effective in protecting against hemolysis and methemoglobin formation. In a hypoxan-thine-xanthine oxidase system, very little hemolysis was observed, whereas remarkable methe-moglobin formation was induced. Catalase was effective in protecting against hemolysis and methemoglobin formation, while no recognizable effect was obtained by the addition of superoxide dismutase. This indicates that hydrogen peroxide is a main participant in methemoglobin for-mation in this system.
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