PCBがコイ肝膵臓の性ホルモン代謝におよぼす影響〔英文〕

概要

論文の詳細を見る
Intraperitoneal administration of 250mg/kg of PCB (Aroclor 1248) to carp stimulated the metabolism of progesterone, estradiol-17β and testosterone by hepatopancreatic microsomes: the activity of progesterone hydroxylase was increased by 148% in the PCB-treated group, while those of estradiol-17β and testosterone hydroxylases were elevated by 30% and 108%, respectively. A significant reduction in plasma sex hormone levels was also observed in the fish treated with PCB: the plasma concentrations of progesterone and estradiol-17β in female carp were lowered by 56% and 26%, respectively, while that of testosterone in male carp was reduced by 53%. This reduc-tion in circulating sex hormones is probably attributable to elevated metabolism of sex hormones in the hepatopancreas. The ability of PCB to alter the plasma levels of sex hormones raises the possibility that PCB accumulated in fish at high concentrations colud have a deleterious effect on fish reproduction.
日本水産學會の論文