異常甲状腺刺激物質とバセドウ病

概要

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It is now widely accepted that thyroid-stimulating antibodies are found in the blood in most, if not all, patients with Graves' disease. Long-acting thyroid stimulator (LATS) was the first such activity to be described. Subsequently, long-acting thyroid stimulator protector (LATS-P) was discovered : this activity was demonstrated in most patients with Graves' disease. In vitro, increased cyclic AMP production in human thyroid tissues after incubation with the patient's serum indicates that a thyroid adenylate cyclase stimulator is present in the serum. Recently, the radioreceptor assay measures the inhibition of 125I-TSH binding to thyroid cell membranes by the sera of Graves' disease. On the other hand, high levels of basal adenylate cyclase activity in the thyroid tissue from the patients especially with possitive thyroid stimulators were reported. These lines of observation suggest that Graves' thyroid tissue may be stimulated by abnormal thyroid stimulators. From these points of view, I discussed in this article on the etiology of Graves' disease.
日本膜学会の論文